Latest Products http://www.talinremedies.co.in Latest Products Thu, 21 Oct 2021 17:18:45 +0530 en-us http://www.talinremedies.co.in Hemored Tablets http://www.talinremedies.co.in/hemored-tablets.htm http://www.talinremedies.co.in/hemored-tablets.htm Tue, 06 Sep 2016 00:00:00 +0530 Generic Name - Ferrous Ascorbate 100 mg + Folic Acid 1.5 mg + Cyanocobalamin 15 mcg+ Zinc 22.5 mg TabletsUse : Most effective for the treatment of ironed deficiency & anemia inclusive of vitamin needs for the human body. Top of Form Bottom of Form Key Benefits are : Ferrous Ascorbate is an antianemic agent. It is an iron supplement, used to treat or prevent iron deficiency anemia. Folic Acid is a Vitamin B which helps the body makes healthy new cells. Especially for women who may get pregnant, it is very important. Cyanocobalamin. Its key role is the normal functioning of the brain and nervous system and for the formation of blood. Zinc is an essential mineral that stimulates the activity of about 100 enzymes in the body. It supports our healthy immune system, to synthesize DNA. It plays important role in healthy development of the body during adolescence, childhood and pregnancy. Rislin Tablets http://www.talinremedies.co.in/rislin-tablets.htm http://www.talinremedies.co.in/rislin-tablets.htm Mon, 05 Sep 2016 00:00:00 +0530 Drug Class and Mechanism : Rislin (risperidone) is an atypical antipsychotic drug that is used for treating schizophrenia, bipolar mania and autism. Other atypical antipsychotic drugs include Olanzapine (Olife), Quetiapine (Taliquel), Ziprasidone , Aripiprazole  and paliperidone . Atypical antipsychotics differ from typical antipsychotics due to the lesser degree of extrapyramidal (movement) side effects and constipation. Details : The exact mechanism of action of  Rislin (risperidone) is not known, but, like other anti-psychotics, it is believed that risperidone affects the way the brain works by interfering with communication among the brain's nerves. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on the nerves. The attachment of the neurotransmitters either stimulates or inhibits the function of the nearby nerves. Risperidone blocks several of the receptors on nerves including dopamine type 2, serotonin type 2, and alpha 2 adrenergic receptors. It is believed that many psychotic illnesses are caused by abnormal communication among nerves in the brain and that by altering communication through neurotransmitters, risperidone can alter the psychotic state. Risperidone was approved by the FDA in December, 1993. Prescription - Yes Preparations - Tab RISLIN® Tablets are available in  1 mg (Brown), 2 mg (orange), Rislin Plus (Red Brown), Risperidone 3 mg +Trihexyphenidyl 2 mg. strengths. rislin® tablets contain the following inactive ingredients: colloidal silicon dioxide, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, propylene glycol, sodium lauryl sulfate, and starch (corn). The 1 mg,  2 mg, PLUS tablets also contain talc and titanium dioxide. Storage - Tablets should be kept at room temperature, 15-25 C (59-77 F)   Prescribed For : Risperidone is used to treat schizophrenia, bipolar mania [as a sole therapy or combination therapy with lithium ,  or valproate (validin, Divolin) and for the treatment of irritability associated with autistic disorder in children and adolescents. Clinical studies involving small numbers of patients have shown some benefit in using risperidone for stuttering and Tourette syndrome (non FDA-approved uses). Another non-FDA approved use of risperidone is for obsessive-compulsive disorders. Dosing : Rislin (risperidone) can be administered once or twice daily. Initial dosing is generally 2 mg/day. Dose increases can occur in increments of 1-2 mg/day, as tolerated, to a recommended dose of 4-8 mg/day. In children, risperidone should be initiated at 0.5 mg once daily, and can be increased in increments of 0.5 or 1 mg/day, as tolerated, to a recommended dose of 2.5 mg/day. Risperidone can be given with or without meals. The recommended dose of Risperdal Consta is 25 mg injected into the deltoid or gluteal muscle every two weeks. Patients who have never received risperidone are started on oral risperidone in order to evaluate tolerability.   Drug Interactions : Risperidone may interfere with elimination by the kidneys of clozapine , a different type of antipsychotic medication, causing increased levels of clozapine in the blood. This could increase the risk of side effects with clozapine. Serotonin reuptake inhibitors such as paroxetine (Paxilin, Sertraline , and fluoxetine  when taken with risperidone causes the metabolism (breakdown) of risperidone by the liver to be inhibited, which in turn causes elevated blood levels of risperidone, and may increase the risk of adverse reactions. Antifungal drugs such as fluconazole , itraconazole , and ketoconazole  when taken with risperidone cause the metabolism (breakdown) of risperidone by the liver to be inhibited, which in turn causes elevated blood levels and may increase the risk of adverse reactions. Pregnancy : There are no adequate studies of risperidone in pregnant women. Some unwanted effects have been reported in animal studies. Risperidone can be used in pregnancy if the physician feels that the benefits outweigh the potential but unknown risks.   Nursing Mothers : Rislin ( risperidone) is excreted in human breast milk. Women receiving risperidone should not breastfeed.   Side Effects : The most commonly-noted side effects associated with risperidone are extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes), dizziness, hyperactivity, tiredness, abdominal pain, fatigue, fever and nausea. Risperidone may cause a condition called orthostatic hypotension during the early phase of treatment (the first week or two). Patients who develop orthostatic hypotension have a drop in their blood pressure when they rise from a lying position and may become dizzy or even lose consciousness. Studies involving risperidone suggest an increased risk of hyperglycemia-related adverse reactions as seen in diabetes. Although there is no clear link between risperidone and diabetes, patients should be tested during treatment for elevated blood sugars. Additionally, persons with risk factors for diabetes, including obesity or a family history of diabetes, should have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetes. Any patient developing symptoms that suggest diabetes during treatment should be tested for diabetes.   Uses : This medication is used to treat schizophrenia and bipolar disorder (manic phase). It works by helping to restore the balance of certain natural substances in the brain (neurotransmitters). Risperidone has not been shown to be safe or effective in the elderly for the treatment of delusions/hallucinations (psychosis) due to dementia.How to Use : Take this medication by mouth exactly as prescribed. This drug may be taken with or without food. During the first few days your doctor may gradually increase your dose to allow your body to adjust to the medication. The dosage is based on your medical condition and response to therapy. Continue to take this medication as directed, even if you are feeling better and thinking more clearly. Do not take this more often or increase your dose without consulting your doctor. Your condition will not improve any faster but the risk of serious side effects will be increased. Do not stop taking this drug without your doctor's approval. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.   Side Effects : Dizziness, drowsiness, fatigue, nausea, constipation, runny nose, weight gain, nervousness, acne, dry skin, difficulty concentrating, decreased sexual ability/desire or difficulty sleeping may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Tell your doctor immediately if any of these serious side effects occur - fainting, rapid/pounding/irregular heartbeat, mental/mood changes, fever, muscle stiffness/spasms/twitching, sweating, uncontrolled muscle movements (e.g., tongue and facial muscles), drooling, difficulty swallowing, seizures. Tell your doctor immediately if any of these unlikely but serious side effects occur: chest pain, one-sided weakness, numbness in the face/arms/legs, sudden vision changes, slurred speech, confusion. This medication may in rare instances increase your blood level of a certain hormone (prolactin). In females, an increase in prolactin levels may result in unwanted breast milk, the end of menstruation or difficulty becoming pregnant. In males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor immediately. This drug may infrequently make your blood sugar level rise, therefore causing or worsening diabetes. This high blood sugar can rarely cause serious (sometimes fatal) conditions such as diabetic coma. Tell your doctor immediately if you develop symptoms of high blood sugar, such as unusual increased thirst and urination. If you already have diabetes, be sure to check your blood sugar level regularly. This drug may also cause significant weight gain and a rise in your blood cholesterol (or triglyceride) levels. These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. (See also Notes section.) Males: In the unlikely event you have a painful, prolonged erection, stop using this drug and seek immediate medical attention or permanent problems could occur. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.   Warning : Increased Mortality in Elderly Patients with Dementia-related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Rislin® (risperidone) is not approved for the treatment of patients with dementia-related psychosis. [See Warnings and Precautions] Talicarb Tablets http://www.talinremedies.co.in/talicarb-tablets.htm http://www.talinremedies.co.in/talicarb-tablets.htm Tue, 06 Sep 2016 00:00:00 +0530 Talicarb SR (Oxcarbazepine) is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. It is also used to treat anxiety and mood disorders, and benign motor tics. Oxcarbazepine is a structural derivative of carbamazepine, with a ketone in place of the carbon-carbon double bond on the dibenzazepine ring. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia or agranulocytosis occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition (presumed to be the main mechanism of action) - and is generally used to treat the same conditions.  Oxcarbazepine has recently been found to be associated with a greater enhancement in mood and reduction in anxiety symptoms than other drugs employed to treat epilepsy.History : First synthesized in 1965, it was patent protected by Geigy in 1969 through DE2011087. It was approved for use as an anticonvulsant in Denmark in 1990, Spain in 1993, Portugal in 1997, and eventually for all other EU countries in 1999. It was approved in the US in 2000.Pharmacology : Oxcarbazepine is a prodrug which is activated to eslicarbazepine in the liver. Side effects : Oxcarbazepine causes dizziness, drowsiness, blurred or double vision, fatigue and may cause headaches, nausea, and vomiting. It can also cause hyponatremia (2.7% of patients), so blood sodium levels should be tested if the patient complains of severe fatigue. Some of these side effects (such as headache) are more pronounced shortly after a dose is taken and tend to fade with the passage of time (generally 60 to 90 minutes). A craving for salty foods (such as potato chips) and increased impulsiveness have also been noted. Other side effects include stomach pain; tremor; rash; diarrhea, constipation, decreased appetite; and dry mouth. Skin sensitivity to sunlight also may increase, and patients could experience severe sunburns as a result of sun exposure. The frequency of adverse effects rises above a daily dosage of 1200 mg. Possible reproductive risks : Oxcarbazapine may cause oral hormonal contraceptives to be less effective. Increased incidences of fetal structural abnormalities and other manifestations of developmental toxicity (embryolethality, growth retardation) were observed in the offspring of animals (rats and rabbits) treated with either oxcarbazepine or its active 10-hydroxy metabolite (MHD) during pregnancy at doses similar to the maximum recommended human dose. There are no adequate and well-controlled clinical studies of oxcarbazepine in pregnant women; however, oxcarbazepine is closely related structurally to carbamazepine, which is considered to be teratogenic in humans. Given this fact, and the results of the animal studies described, it is likely that oxcarbazepine is a human teratogen. Oxcarbazepine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nursing mothers : Oxcarbazepine and its active metabolite MHD are excreted in human breast milk. Because of the potential for serious adverse reactions to oxcarbazepine in nursing infants, a decision should be made about whether to discontinue nursing or to discontinue the drug in nursing women, taking into account the importance of the drug to the mother. Talicetam Tablets http://www.talinremedies.co.in/talicetam-tablets.htm http://www.talinremedies.co.in/talicetam-tablets.htm Tue, 06 Sep 2016 00:00:00 +0530 Talicetam (Piracetam)is a nootropic drug. It appears to enhance cognition and memory, slow brain aging, increase blood flow and oxygen to the brain, aid stroke recovery, and ameliorate Alzheimer's, Down's syndrome, dementia, and dyslexia, among other diseases and conditions. Piracetam's chemical name is 2-oxo-1-pyrrolidine acetamide; it shares the same 2-oxo-pyrrolidone base structure with 2-oxo-pyrrolidine carboxylic acid (pyroglutamate). Piracetam is a cyclic derivative of GABA. It is one of the racetams. Piracetam is prescribed by doctors for some conditions, mainly myoclonus, but is used off-label for a much wider range of applications.   Pharmacokinetics : Piracetam protects the cerebral cortex against hypoxia. It also inhibits platelet aggregation and reduces blood viscosity.Piracetam Adverse Reactions / Piracetam Side Effects : Hyperkinesia, nervousness, depression, diarrhoea, rashes. CNS stimulation, sleep disturbances, dizziness, excitement, insomnia, somnolence, weight gain.Special Precautions : Avoid abrupt withdrawal. Impaired renal function. Cardiac disorders. Haemostatic disorders. Patients who have recently undergone major surgery. Elderly.Other Drug Interactions : May increase prothrombin time in patients who are on warfarin.   Dosage : Oral Adjunct in cortical myoclonus Adult - 7.2 g daily in 2-3 divided doses, increased by 4.8 g/day every 3-4 days. Max dose - 20 g daily.   Food(before/after) Should be taken with food. (Take before meals.) List of Contraindications Piracetam and Pregnancy Contraindicated in pregnancy Piracetam and Lactation Contraindicated in lactation Piracetam and Other Contraindications Hepatic and severe renal impairment. Cerebral haemorrhage. Pregnancy and lactation. Talimem Tablets http://www.talinremedies.co.in/talimem-tablets.htm http://www.talinremedies.co.in/talimem-tablets.htm Tue, 06 Sep 2016 00:00:00 +0530 Talimem  contains a combination of donepezil and memantine. Donepezil improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning. Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease.   Details : Talimem  is used to treat moderate to severe dementia of the Alzheimer's type. Talimem   is not a cure for Alzheimer's disease. This condition will progress over time, even in people who take donepezil. Before taking this medicine You should not use Talimem if you are allergic to donepezil or memantine. How should I take Talimem ? Take Talimem exactly as prescribed by your doctor . Thimore Tablets http://www.talinremedies.co.in/thimore-tablets.htm http://www.talinremedies.co.in/thimore-tablets.htm Tue, 06 Sep 2016 00:00:00 +0530 Thimore-100 (Thiamine) is a vitamin, also called vitamin B1. Vitamin B1 is found in many foods including yeast, cereal grains, beans, nuts, and meat. It is often used in combination with other B vitamins, and found in many vitamin B complex products. Vitamin B complexes generally include vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid. However, some products do not contain all of these ingredients and some may include others, such as biotin, para-aminobenzoic acid (PABA), choline bitartrate, and inositol.   Details : People take thiamine for conditions related to low levels of thiamine (thiamine deficiency syndromes), including beriberi and inflammation of the nerves (neuritis) associated with pellagra or pregnancy. Thimore-100 (Thiamine) is also used for digestive problems including poor appetite, ulcerative colitis, and ongoing diarrhea. Thimore-100 (Thiamine) is also used for AIDS and boosting the immune system, diabetic pain, heart disease, alcoholism, aging, a type of brain damage called cerebellar syndrome, canker sores, vision problems such as cataracts and glaucoma, motion sickness, and improving athletic performance. Other uses include preventing cervical cancer and progression of kidney disease in patients with type 2 diabetes. Some people use thiamine for maintaining a positive mental attitude; enhancing learning abilities; increasing energy; fighting stress; and preventing memory loss, including Alzheimer's disease. Healthcare providers give thiamine shots for a memory disorder called Wernicke's encephalopathy syndrome, other thiamine deficiency syndromes in critically ill people, alcohol withdrawal, and coma.   How effective is it? : Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.   The effectiveness ratings Thimore (vitamin B1) are as follows: Effective for Metabolic disorders. Taking thiamine by mouth helps correct metabolic disorders associated with genetic diseases, including Leigh's disease, maple syrup urine disease, and others. Thiamine deficiency. Taking thiamine by mouth helps prevent and treat thiamine deficiency. Brain disorder due to thiamine deficiency (Wernicke-Korsakoff syndrome). Thiamine helps decrease the risk and symptoms of a specific brain disorder called Wernicke-Korsakoff syndrome (WKS). This brain disorder is related to low levels of thiamine (thiamine deficiency) and is often seen in alcoholics. Between 30% and 80% of alcoholics are believed to have thiamine deficiency. Giving thiamine shots seems to help decrease the risk of developing WKS and decrease symptoms of WKS during alcohol withdrawal. Possibly effective for Cataracts. High thiamine intake as part of the diet is associated with a reduced risk of developing cataracts. Kidney disease in people with diabetes. Early research shows that taking high-dose thiamine (100 mg three times daily) for 3 months decreases the amount of albumin in the urine in people with type 2 diabetes. Albumin in the urine is an indication of kidney damage. Painful menstruation (dysmenorrhea). Early research suggests that taking thiamine for 90 days stops pain associated with menstruation in girls 12-21 years-old. Possibly ineffective for : Repelling mosquitos. Some research shows that taking B vitamins, including thiamine, does not help repel mosquitos. Insufficient evidence to rate effectiveness for. Athletic performance. Some research suggests that taking thiamine together with pantethine and pantothenic acid (vitamin B5) does not improve muscle strength or endurance in athletes. Preventing cervical cancer. Some research suggests that increasing intake of thiamine from dietary and supplement sources, along with other folic acid, riboflavin, and vitamin B12, might decrease the risk of precancerous spots on the cervix.Poor appetite. Ulcerative colitis. Chronic diarrhea. Stomach problems. Brain conditions. AIDS. Heart disease. Alcoholism. Stress. Aging. Canker sores. Other conditions. More evidence is needed to rate thiamine for these uses.   How does it work? : Thiamine is required by our bodies to properly use carbohydrates.Are there safety concerns? : Thiamine is Likely Safe when taken by mouth in appropriate amounts, although rare allergic reactions and skin irritation have occurred. It is also Likely Safe when given appropriately intravenously (by IV) by a healthcare provider. Thiamine shots are an FDA-approved prescription product. Thiamine might not properly enter the body in some people who have liver problems, drink a lot of alcohol, or have other conditions.Special precautions & warnings : Pregnancy and breast-feeding: Thiamine is Likely Safe for pregnant or breast-feeding women when taken in the recommended amount of 1.4 mg daily. Not enough is known about the safety of using larger amounts during pregnancy or breast-feeding.   Are there interactions with medications? It is not known if this product interacts with any medicines. Before taking this product, talk with your health professional if you take any medications.   Are there interactions with herbs and supplements? Areca : Areca (betel) nuts change thiamine chemically so it doesn't work as well. Regular, long-term chewing of betel nuts may contribute to thiamine deficiency. Horsetail : Horsetail (Equisetum) contains a chemicalthat can destroy thiamine in the stomach, possibly leading to thiamine deficiency. The Canadian government requires that equisetum-containing products be certified free of this chemical. Stay on the safe side, and don't use horsetail if you are at risk for thiamine deficiency. Are there interactions with foods? Coffee and tea : Chemicals in coffee and tea called tannins can react with thiamine, converting it to a form that is difficult for the body to take in. This could lead to thiamine deficiency. Interestingly, thiamine deficiency has been found in a group of people in rural Thailand who drink large amounts of tea (>1 liter per day) or chew fermented tea leaves long-term. However, this effect hasn't been found in Western populations, despite regular tea use. Researchers think the interaction between coffee and tea and thiamine may not be important unless the diet is low in thiamine or vitamin C. Vitamin C seems to prevent the interaction between thiamine and the tannins in coffee and tea. Seafood : Raw freshwater fish and shellfish contain chemicals that destroy thiamine. Eating a lot of raw fish or shellfish can contribute to thiamine deficiency. However, cooked fish and seafood are OK. They don't have any effect on thiamine, since cooking destroys the chemicals that harm thiamine.   What dose is used? The following doses have been studied in scientific research : By Mouth : For adults with somewhat low levels of thiamine in their body (mild thiamine deficiency): the usual dose of thiamine is 5-30 mg daily in either a single dose or divided doses for one month. The typical dose for severe deficiency can be up to 300 mg per day. For reducing the risk of getting cataracts : a daily dietary intake of approximately 10 mg of thiamine. As a dietary supplement in adults, 1-2 mg of thiamine per day is commonly used. The daily recommended dietary allowances (RDAs) of thiamine are: Infants 0-6 months, 0.2 mg; infants 7-12 months, 0.3 mg; children 1-3 years, 0.5 mg; children 4-8 years, 0.6 mg; boys 9-13 years, 0.9 mg; men 14 years and older, 1.2 mg; girls 9-13 years, 0.9 mg; women 14-18 years, 1 mg; women over 18 years, 1.1 mg; pregnant women, 1.4 mg; and breast-feeding women, 1.5 mg. By Injection : Healthcare providers give thiamine shots for treating and preventing symptoms of alcohol withdrawal (Wernicke-Korsakoff syndrome).   Other Names : Aneurine Hydrochloride, Antiberiberi Factor, Antiberiberi Vitamin, Antineuritic Factor, Antineuritic Vitamin, B Complex Vitamin, Chlorhydrate de Thiamine, Chlorure de Thiamine, Complexe de Vitamine B, Facteur Anti-beriberi, Facteur Antineuritique, Hydrochlorure de Thiamine, Mononitrate de Thiamine, Nitrate de Thiamine, Thiamine Chloride, Thiamine HCl, Thiamine Hydrochloride, Thiamin Mononitrate, Thiamine Mononitrate, Thiamine Nitrate, Thiaminium Chloride Hydrochloride, Tiamina, Vitamin B1, Vitamin B-1, Vitamina B1, Vitamine Anti-beriberi, Vitamine Antineuritique, Vitamine B1. Mandrive Tablets http://www.talinremedies.co.in/mandrive-tablets.htm http://www.talinremedies.co.in/mandrive-tablets.htm Tue, 06 Sep 2016 00:00:00 +0530 Mandrive for ED+BPH (erectile dysfunction + symptoms of benign prostatic hyperplasia) Pharmacology : Inhibition of phosphodiesterase type 5 (PDE5) by tadalafil increases the concentrations of cyclic guanosine monophosphate (cGMP), resulting in relaxation of pulmonary vascular smooth muscle cells and vasodilation of the pulmonary vascular bed. Mandrive-20 : Enhances the effect of nitric oxide at the nerve ending and endothelial cells in the corpus cavernosum by inhibiting PDE5 in the corpus cavernosum of the penis. This results in vasodilation, increased inflow of blood into the corporus cavernosum, and ensuing penile erection upon sexual stimulation.FDA Drug Approvals 2013   Pharmacokinetics Absorption Bioavailability undetermined. T max is 2 to 8 h. Steady state is attained within 5 days of once-daily dosing. Distribution : Tadalafil is 94% protein bound   Metabolism : Predominantly metabolized by CYP3A4 to a catechol metabolite, which undergoes further metabolism to the major circulating metabolite, methylcatechol glucuronide.   Elimination : The terminal half-life is 15 h to 17.5 h. Tadalafil is excreted predominantly as metabolites, mainly in the feces (approximately 61%) and to a lesser degree in the urine (approximately 36%). Special Populations : Renal Function Impairment : Tadalafil exposure (AUC) doubled in subjects with CrCl 31 to 80 mL/min. In patients with ESRD on hemodialysis, there was a 2-fold increase in C max and 2.7- to 4.8-fold increase in AUC. Hepatic Function Impairment : Tadalafil exposure (AUC) after a 10 mg dose in patients with mild or moderate hepatic impairment (Child-Pugh class A or B) was comparable with exposure in healthy subjects. There are insufficient data for subjects with severe hepatic impairment. Elderly : Subjects older than 65 y have a 25% higher exposure compared with subjects 19 to 45 y of age. Children : Tadalafil has not been evaluated in patients younger than 18 y. Gender : No clinically relevant differences in AUC and C max have been observed. Race : No differences in the typical exposure to tadalafil have been identified among different ethnic groups. Diabetes mellitus  : AUC was reduced approximately 19% and C max was 5% lower in patients with diabetes mellitus than in healthy subjects. Indications and Usage : Treatment of pulmonary arterial hypertension ; treatment of erectile dysfunction, treatment of benign prostatic hyperplasia , and the treatment of combined erectile dysfunction and BPH.   Unlabeled Uses : Raynaud phenomenon. Contraindications : Administration with organic nitrates (regularly and/or intermittently); serious hypersensitivity to tadalafil.   Dosage and Administration : Benign Prostatic Hyperplasia (With or Without Concomitant Erectile Dysfunction) Adults PO 5 mg once daily, taken at approximately the same time every day without regard to sexual activity. Pulmonary Arterial Hypertension : Adults PO 40 mg once daily. Erectile Dysfunction : Adults For use as needed PO 10 mg prior to anticipated sexual activity. The dose may be adjusted to 5 or 20 mg based on efficacy and tolerability. The max recommended frequency is once per day for most patients. Once-daily use : PO Start with 2.5 mg once daily, taken at approximately the same time each day, without regard to timing of sexual activity. The dosage may be increased to 5 mg daily based on individual efficacy and tolerability. Taliderm Lotion http://www.talinremedies.co.in/taliderm-lotion.htm http://www.talinremedies.co.in/taliderm-lotion.htm Tue, 13 Sep 2016 00:00:00 +0530 Taliderm –S  Clobetasol : Is a glucocorticoid that is highly useful in dermatitis More effective than calcipotriol, camptothecin and tazarotene. Immunopharmacol Immunotoxicol.   Salicylic Acid : Acts as an anti-inflammatory, bactericidal & anti-septic   Indications : Psoriasis Eczema Skin Disorders involving scaling, itching & inflammation   Details : Taliderm- S Ointment 0.05% is a topical skin ointment used to treat dry resistant hyperkeratotic skin conditions, in which the outer layer of the skin becomes thickened, dry and scaly.  These conditions include recalcitrant eczema (difficult to treat), dermatitis, lichen planus (itchy swollen rash on the skin, mouth or tongue) and Ichthyosis vulgaris (accumulation of dry dead skin in patches that look like fish scales) and moderate to severe plaque psoriasis (thickening of the skin).also used to treat acne, to clear pimples and blemishes. Taliderm-s Cream is a topical skin cream used to treat melasma, a chronic skin disorder characterised by symmetrical, blotchy, brownish facial pigmentation.  Melasma is caused by over production of melanin by the pigment-producing cells melanocytes.  It is thought to have a genetic predisposition and may be triggered by various factors including sun exposure, pregnancy, hormone treatments, some toiletries, and hypothyroidism (low thyroid hormone).  Glowlite Cream is a combination treatment that lightens the skin and reduces the risk of dermatitis, inflammation of the skin that can be associated with using skin lighteners alone to treat Melasma.(Meatasar ht this combination of medications for treatment of melasma has been found to provide better improvement than treatment with a single medication.   For Treatment of Skin Hyperplgmentation : Lightens Dark Patches of Skin Provides Fast Relief & Clinically Tested For Fair and Blemish Free Skin Taliket Lotion http://www.talinremedies.co.in/taliket-lotion.htm http://www.talinremedies.co.in/taliket-lotion.htm Tue, 13 Sep 2016 00:00:00 +0530 Uses : This medication is used to treat a certain skin condition (seborrheic dermatitis, a type of dandruff). In this condition, it is believed that a fungus (Malassezia furfur) infects the skin or scalp, resulting in dry, flaky skin (scales) on the scalp, face, ears, chest, or upper back. Ketoconazole is an azole antifungal drug that works by stopping the growth of fungus.   How to use ketoconazole-pyrithione zinc topical : Read the Patient Information on the box.Use this medication on the scalp and skin only. Clean and thoroughly dry the area to be treated. Wash hands before and after applying this medication. Apply it to the affected skin and also to a small amount of the normal skin next to this area, usually once a day or as directed by your doctor. Do not get this medication in the eyes, nose, or mouth. If this occurs, flush with plenty of water. If irritation occurs, contact your doctor right away. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.   Side Effects : Burning, redness, or dryness of the treated skin may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.   Precautions : Before using ketoconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals such as clotrimazole, econazole, or miconazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Sunscreen Lotion http://www.talinremedies.co.in/sunscreen-lotion.htm http://www.talinremedies.co.in/sunscreen-lotion.htm Mon, 05 Sep 2016 00:00:00 +0530 We have well-connected and huge warehouse that helps us in keeping large stock under suitable conditions. Also, we keep it updated to meet set industry standards. We have a good rapport with the prominent e-commerce merchants who provide us a secure payment gateway. With this, we guarantee instant and hassle free transactions. Main ingredient with uses detail : Methylparaben(0.2%) is an anti-fungal agent often used in a variety of cosmetics and personal-care products. It is also used as a food preservative and has the E number E218. Propylparaben,(0.1%) the n-propyl ester of p-hydroxybenzoic acid, occurs as a natural substance found in many plants and some insects, although it is manufactured synthetically for use in cosmetics, pharmaceuticals and foods. It is a preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. As a food additive, it has the E number E216. Medicinal liquid paraffin,(5%) also known as paraffinum liquidum, is a very highly refined mineral oil used in cosmetics and for medical purposes(Emollient). This is a UK definition (British Pharmacopoeia) and the term may have different uses in other countries. The cosmetic or medicinal liquid paraffin should not be confused with the paraffin (or kerosene) used as a fuel. Emulsifying Wax (3%) is used to prevent oil and water from separating in creams and lotions. cetostearyl alcohol (2%)cetearyl alcohol or cetylstearyl alcohol[1] is a mixture of fatty alcohols, consisting predominantly of cetyl and stearyl alcohols and is classified as a fatty alcohol. It is used as an emulsion stabilizer, opacifying agent, and foam boosting surfactant, as well as an aqueous and nonaqueous viscosity-increasing agent. Glycerol monostearate,(2%) commonly known as GMS, is an organic molecule used as an emulsifier.[1] GMS is a colorless, odorless, and sweet-tasting flaky powder that is hygroscopic. It is a glycerol ester of stearic acid. It occurs naturally in the body as a by-product of the breakdown of fats, and is also found in fatty foods. GMS is a food additive used as a thickening, emulsifying, anti-caking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant. It is also used in cosmetics and hair care products. Dimethicone(1%)(also known as polydimethylsiloxane or PDMS) is technically called a silicone-based polymer. More simply, it’s a silicone oil with certain properties that make it extremely popular in today’s personal care properties.  It fills in uneven texture and fine lines, which helps create a smooth and flawless look in products like primers, foundations, and lotions. It also provides a protective cover on skin, which is supposed to help keep moisture in, leaving skin hydrated for longer &  protect from Radiation. Oxybenzone or benzophenone-3(2.5%) is an organic compound used in sunscreens. It is one of the most widely used organic UVA filters in sunscreens today. Oxybenzone belongs to the class of aromatic ketones known as benzophenones. It provides broad-spectrum UV coverage, including UVB and short-wave UVA (ultraviolet) rays. As a photoprotective agent, it has an absorption profile spanning from 270 to 350 nm with absorption peaks at 288 and 350 nm. Use a minimum of SPF 15 and reapply every hour or two at the very most. To see how long your sunscreen will last under perfect conditions, take the number of SPF and multiply it by 10. That is the length of time you'd be safe from the sun's rays. (In perfect conditions - No water or sweating taken into account here.) For example : SPF 20 x 10 = 200 minutes of sun protection Titanium dioxide(2.5%) is found in almost every sunscreen with a physical blocker because of its high refractive index, its strong UV light absorbing capabilities and its resistance to discolouration under ultraviolet light. This advantage enhances its stability and ability to protect the skin from ultraviolet light. Nano-scaled titanium dioxide particles are primarily used in sun screen lotion because they scatter visible light less than titanium dioxide pigments while still providing UV protection.[25] Sunscreens designed for infants or people with sensitive skin are often based on titanium dioxide and/or zinc oxide, as these mineral UV blockers are believed to cause less skin irritation than other UV absorbing chemicals. Iron-Oxide Red (0.1%)  is a Colour. Octyl methoxycinnamate(10%) (INCI)  is an organic compound that is an ingredient in some sunscreens and lip balms. Octyl methoxycinnamate (octinoxate) is a chemical sun blocking agent that absorbs ultraviolet radiation in UVB range. It is an ester formed from methoxycinnamic acid and (RS)-2-ethylhexanol. It is a clear liquid that is insoluble in water. Its primary use is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage. It is also used to reduce the appearance of scars. Imidazolidinyl urea(0.1%) is an antimicrobial preservative used in cosmetics Glycerin (2%)Glycerin is a natural emollient and has a cooling effect on skin. Being a humectant (which means that it attracts water, i.e. moisture), it draws oxygen into the skin thus helping it retain moisture. Tocopheryl Acetate (0.5%) Vitamin E is an antioxidant that protects body tissue from damage caused by unstable substances called free radicals. Free radicals can harm cells, tissues, and organs. They are believed to play a role in certain conditions associated with aging. Vitamin E skin care benefits : Helps to protect the skin from UV damage. Improves the skin texture and the moisture content in the skin. Reduces the severity of sunburns. Increases the effect of sunscreen ingredients. Inhibition of lipoperoxide associated skin disorders. Prevents of melanin deposits. Potent anti-inflammatory ingredient. Improves the stability of cosmetics. Daucus Carota Extract (1%) Carrot seed oil is the essential oil extract of the seed from the carrot plant Daucus carota. The oil has a woody, earthy sweet smell Citrullus Vulgaris (0.5%) Watermelon Oil is a wonderful emollient,Non-greasy oil. Watermelon Seed Oil Properties : Light in Texture Non-Greasy Penetrating Absorbs Quickly Highly Moisturizing Emollient Rich in Omega 6 Essential Fatty Acids and Omega 9 Fatty Acids Dissolves Sebum Buildup Stable Shelf-Life Aloe barbadenis extract (1%) Aloe barbadensis is just one of the four varieties of Aloe Vera. Products with Aloe barbadensis content are known to improve moisture and reduce skin inflammation as well. Hair care products with Aloe barbadensis are perfect to repair dry and dull hair and scalp. This is a common ingredient in shampoos, conditioners, and hair tonics used to reduce the effect of male pattern baldness. Demineralised Water (66.1 %) Demineralised (MD) water is another name for Deionized (DI) water. This water is completely free (or almost) of dissolved minerals as a result of any of process viz. distillation, deionization, membrane filtration (reverse osmosis or nano-filtration), electrodyalisis or other technologies. Clinsoft Face Wash http://www.talinremedies.co.in/clinsoft-face-wash.htm http://www.talinremedies.co.in/clinsoft-face-wash.htm Tue, 13 Sep 2016 00:00:00 +0530 Why is this medication prescribed?Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid treats acne by reducing swelling and redness and unplugging blocked skin pores to allow pimples to shrink. It treats other skin conditions by softening and loosening dry, scaly, or thickened skin so that it falls off or can be removed easily.How should this medicine be used?  Topical salicylic acid may be used as often as several times a day or as infrequently as several times a week, depending on the condition being treated and the product being used. Follow the directions on the package label or your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use salicylic acid exactly as directed. Do not use more or less of it or use it more often than directed on the package or prescribed by your doctor. Do not swallow topical salicylic acid. Be careful not to get topical salicylic acid in your eyes, nose, or mouth. If you accidentally get topical salicylic acid in your eyes, nose, or mouth, flush the area with water for 15 minutes. Do not apply topical salicylic acid to skin that is broken, red, swollen, irritated, or infected.   What special precautions should I follow? : Before using topical salicylic acid, Tell your doctor and pharmacist if you are allergic to salicylic acid, any other medications, or any of the ingredients in salicylic acid products. Ask your pharmacist or check the package label for a list of the ingredients.   What side effects can this medication cause? : Topical salicylic acid may cause side effects. Tell your doctor if either of these symptoms are severe or do not go away : skin irritation stinging in the area where you applied topical salicylic acid If you experience any of the following symptoms, stop using salicylic acid and call your doctor immediately Itching Throat tightness Swelling of the eyes, face, lips, or tongue etc. Laxilin Syrup http://www.talinremedies.co.in/laxilin-syrup.htm http://www.talinremedies.co.in/laxilin-syrup.htm Mon, 05 Sep 2016 00:00:00 +0530 Laxilin Plus Syrup is an oral emulsion made from Milk of Magnesia, Liquid Paraffin and Picosulfate BP. Laxilin  PLUS Syrup is a refreshing flavour oral laxative stool softener that provides immediate chronic constipation relief. Laxilin  Plus Syrup is indicated in symptoms such as acute constipation, painful rectum hemorrhoids, external piles and other anorectal disorders such as anal fistula and hernia. Laxilin Plus Syrup eases bowel evacuation in irregular bowel syndrome (IBS) and post-operative constipation disorders.Laxilin Plus Syrup Indications : Acute Constipation Piles Hemorrhoids Fistula Hernia Post Operative Constipation Anal Fissure   Laxilin Plus Syrup Dosage : As directed by a physician or your medical practitioner. Laxilin Plus Syrup is best taken at bedtime preferably with a glass of water. Laxilin Plus Syrup Composition : (Ingredients per 5 ml) Liquid Paraffin I.P. - 1.25 ml Milk of Magnesia I.P. - 3.75 ml Sodium Picosulfate B.P. - 3.33 mg Colours – Approved colour used   Warning : laxilin Plus Syrup is Contradicted in Nausea, Vomiting and Abdominal Pain. Prolonged Use of this Product is Not Recommended. Keep Away from Children. Contradicted in Pregnancy. Shake Bottle Well Before Use. Metastar Cream http://www.talinremedies.co.in/metastar-cream.htm http://www.talinremedies.co.in/metastar-cream.htm Mon, 05 Sep 2016 00:00:00 +0530 The company shares glorious credentials with the leading Suppliers of Metastar Cream and offers the best deal. Being a quality-conscious firm, we are offering nothing short of the best quality products from Amritsar(India).   What is Metastar-ht Cream used for?Metastar-HT Cream is a topical skin cream used to treat melasma, a chronic skin disorder characterised by symmetrical, blotchy, brownish facial pigmentation.  Melasma is caused by over production of melanin by the pigment-producing cells melanocytes.  It is thought to have a genetic predisposition and may be triggered by various factors including sun exposure, pregnancy, hormone treatments, some toiletries, and hypothyroidism (low thyroid hormone).  Metastar -HT Cream is a combination treatment that lightens the skin and reduces the risk of dermatitis, inflammation of the skin that can be associated with using skin lighteners alone to treat Melasma.   How does Metastar-ht Cream work? Metastar-HT Cream contains a combination of medications that are used together to treat the chronic skin disorder melasma.  The production of melanin is controlled by the enzyme tyrosine, which is found in the melanosomes of melanocytes.  Hydroquinone in Metastar-HT Cream is a tyrosinase inhibitor that works by blocking the action of tyrosinase, which inhibits the formation of melanin by melanocytes.  It also increases the breakdown of melanosomes that contain the melanin.   As the amount of melanin produced decreases the darkened skin gradually lightens to match normal skin colour.  Tretinoin in Metastar-HT Cream is an active metabolite of Vitamin A and is a keratolytic medication that works by binding to specific retinoic acid receptors in the nucleus of skin cells and affects the way skin cells behave, which regulates cell growth and differentiation; it also has anti-inflammatory properties.  Tretinoin is thought to act by enhancing skin epithelial cell proliferation and accelerating epithelial differentiation; it also blocks the hardening processes of the outer skin layer (keratinisation and cornification) and increases the shedding of old hardened skin cells, while at the same time promoting growth of new skin cells.  The combined effect of these actions is to speed up skin cell turnover which has the effect of lightening the skin. Metasar-HT Cream also contains the synthetic corticosteroid mometasone, which is a medium potency anti-inflammatory that is often used for topical application as it concentrates in the skin but does not enter the blood circulation and, therefore, has minimal systemic effect.  Mometasone in Metasar-HT Cream works by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes; and also narrows and constricts causes blood vessels that have become dilated (widened) and leaky allowing other inflammatory cells into the skin to escalate the inflammatory response.  The antiinflammatory actions of Mometasone in Metastar-HT Cream reduce the risk of developing contact dermatitis that may be caused by hydroquinone and tretinoin.  This combination of medications for treatment of melasma has been found to provide better improvement than treatment with a single medication.   What does Metasar-HT Cream contain? Metasar-HT Cream contains the active ingredients Mometasone Furoate 0.1% (w/w), Hydroquinone 2.0% (w/w), Tretinoin 0.025% (w/w) in a cream base.   Treating Melasma with Metasar-HT Cream Metasar-HT Cream is a topical skin cream containing a combination of medications that are used together to treat the chronic skin disorder melasma.    Melasma is characterised by symmetrical, blotchy, brownish facial pigmentation caused by over production of melanin by the pigment-producing cells melanocytes.  It is thought to have a genetic predisposition and may be triggered by various factors including sun exposure, pregnancy, hormone treatments, some toiletries, and hypothyroidism (low thyroid hormone).  The production of melanin is controlled by the enzyme tyrosine in melanocytes.  Hydroquinone in Metastar-HT Cream is a tyrosinase inhibitor that inhibits the formation of melanin by melanocytes and thereby lightens the skin.  Tretinoin in Metastar-HT Cream is a keratolytic with anti-inflammatory properties that works by binding to specific retinoic acid receptors in the nucleus of skin cells to regulate growth and differentiation, by enhancing skin epithelial cell proliferation and accelerating epithelial differentiation.  Tretinoin in Metastar-HT Cream also blocks the hardening processes of the outer skin layer (keratinisation and cornification) and increases the shedding of old hardened skin cells, while at the same time promoting growth of new skin cells.  This speeds up skin cell turnover which has the effect of lightening the skin.  Mometasone in Metastar-HT Cream is a corticosteroid anti-inflammatory that works by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes; and also narrows and constricts causes blood vessels that have become dilated (widened) and leaky allowing other inflammatory cells into the skin to escalate the inflammatory response.  This action of Mometasone in Metastar-HT Cream reduces the risk of developing contact dermatitis that may be caused by hydroquinone and tretinoin.  This combination of medications for treatment of melasma has been found to provide better improvement than treatment with a single medication.   What are the side effects of Metastar-HT Cream?The most commonly reported side effects when using Metastar-HT Cream include burning, stinging, dryness, scaling, redness (erythema), skin sensitivity and contact dermatitis at the site of application. When should Metastar-HT Cream not be used?You should not use Metastar-HT Cream if you : are allergic to mometasone, hydroquinone, tretinoin or any ingredients in Metastar-HT Cream are pregnant or are breastfeeding, as tretinoin may cause birth defects have acute eczema, as tretinoin can cause severe irritation on eczematous skin have a skin condition such as rosacea or perioral dermatitis have a personal or familial history of cutaneous epithelioma are using benzoyl peroxide, hydrogen peroxide, or other peroxide products with Metastar-HT Cream, as this combination may cause a temporary darkening of the skin. have a viral infection of the skin, tuberculosis, acne rosacea (a chronic skin condition), perioral dermatitis (facial rash around the mouth), fungal skin infections and ulcerative conditions have damaged skin are using any topical skin peeling medication containing sulphur, resorcinal or salicylic acid are exposed to sunlight for prolonged periods.  If unavoidable use a sunscreen and protective clothing over treated areas to protect the skin.   How should Metastar-HT Cream be used?You should apply your Metastar-HT Cream to the affected area of the skin once or twice daily.  Clean the skin with a mild soap or soap-free cleanser, rinse with water then apply a small amount with clean fingers and rub gently into the skin. Do not use large amounts or apply more often than directed.  Avoid contact with the eyes, eyelids, inside of the nose and mouth, which are easily irritated areas, or other areas where treatment is not intended. Do not apply to severely inflamed skin or to open lesions. You should continue to use Metastar-HT Cream as long as recommended by your doctor, which may be for several weeks of months. How long should you use Metastar-HT Cream?You should continue to use Metastar-HT Cream as long as recommended by your doctor, which may be for several weeks of months. Missed dose of Metastar-HT CreamIf you miss a dose of Metastar-HT Cream apply it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.How should Metastar-HT Cream be stored?You should store your Metastar-HT Cream below 25oC in a cool dry place. Migracool Capsules http://www.talinremedies.co.in/migracool-capsules.htm http://www.talinremedies.co.in/migracool-capsules.htm Mon, 05 Sep 2016 00:00:00 +0530 Propranolol is a non-selective beta blocker mainly used in the treatment of hypertension. It was the first successful beta blocker developed. It is the only drug proven effective for the prophylaxis of migraines in children. Pharmacokinetics : Propranolol competitively blocks β1- and β2-receptors resulting to decreased heart rate myocardial contractility, BP and myocardial oxygen demand. It only possesses membrane-stabilising properties.Propranolol information from Drugs Update  P - Contraindicated in pregnancy L - Caution when used during lactation LI - Lab *   AbsorptionAlmost completely absorbed from the GI tract (oral); peak plasma concentrations after1 hour.   Distribution : Crosses the blood-brain barrier and placenta, enters breast milk. Protein-binding - 90%. Metabolism : Hepatic; yields 4-hydroxypropranolol (biologically active). Excretion : Via urine (as metabolites and small amounts of unchanged drug); 3-6 hours (elimination half-life). May be removed by dialysis.   Propranolol Adverse Reactions / Propranolol Side Effects : Cold extremities, insomnia, fatigue, dizziness, vivid dreams, lassitude, nausea, constipation or diarrhoea, vomiting, anorexia, stomach discomfort, impotence. Weakness, paraesthesia, wheezing, pharyngitis, bronchospasm. CNS disturbances at higher doses and mood alterations. Thrombocytopenic purpura, agranulocytosis, nonthrombocytopenic purpura, thrombocytopenia. Depression, confusion, cognitive dysfunction, emotional lability, fatigue, hallucinations. Potentially Fatal : Heart failure, heart block and bronchospasm.   Precautions Propranolol should be used with caution in patients with impaired hepatic or renal function. Propranolol hydrochloride extended- release is not indicated for the treatment of hypertensive emergencies. Beta-adrenergic receptor blockade can cause reduction of intraocular pressure. Patients should be told that Propranolol hydrochloride extended-release may interfere with the glaucoma screening test. Withdrawal may lead to a return of increased intraocular pressure. While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. Overdosage : Severe and occasionally fatal CV depression.     Special Precautions : Compensated heart failure, peripheral vascular disease, diabetes. Switching from conventional to sustained-release preparations, elderly. Ischaemic heart disease, congestive cardiac failure, renal or hepatic dysfunction. Increased risk of bradycardia and hypotension in patients with underlying cardiac disorders. 1st degree heart block. May mask symptoms of hyperthyroidism and hypoglycaemia. May unmask myasthenia gravis. Abrupt withdrawal may lead to angina, MI, ventricular arrhythmias and death. Lactation.   Other Drug Interactions :Decreased effect with aluminum and calcium salts, NSAIDs, ampicillin, rifampicin. Concurrent use with chlorpromazine results in raised blood levels of both drugs and additive hypotensive effect. Hypotensive effect reduced by indometacin. Additive effect with other antihypertensives and diuretics. May reduce the clearance of bupivacaine. Plasma levels may be increased by hydralazine and propafenone. Increased serum levels of thioridazine when used with propranolol.Potentially Fatal : Marked hypertension and bradycardia with adrenaline. Rebound hypertension due to abrupt withdrawal of clonidine is potentiated. Severe bradycardia may occur with digitalis. Dosage Oral Hypertension Adult - As conventional tablet or oral solution: Initially, 40-80 mg bid. Usual range: 160-320 mg daily. As extended release tablet: Initially, 80 mg once daily. Usual range: 120-160 mg once daily. Max - 640 mg daily. Child - Initially, 1 mg/kg daily in divided doses, may increase to 2-4 mg/kg daily in 2 divided doses. Phaeochromocytoma Oral Adult - 60 mg daily given on the 3 days before the operation with α-blockade. Prolonged treatment of 30 mg daily may be given if tumour is inoperable. Child - 250-500 mcg/kg 3-4 times daily. Myocardial infarction Oral Adult - 40 mg 4 times daily for 2-3 days followed by 80 mg bid. Alternatively, 180-240 mg daily in divided doses. Doses to be given within 5-21 days of MI.   Cardiac arrhythmias Oral Adult - 30-160 mg daily in divided doses. Child - 250-500 mcg/kg 3-4 times daily. Prophylaxis of migraine Oral Adult - Initially, 40 mg bid-tid increased to 160 mg daily. Up to 240 mg daily may be necessary. Discontinue therapy if satisfactory response not obtained within 4-6 weeks after reaching max dose. Child - <12 years: 20 mg bid-tid. Portal hypertension Oral Adult - Initially, 40 mg bid increased up to 160 mg bid. Angina pectoris Oral Adult: As conventional tablet or oral solution: 40 mg bid-tid, may increase to 120-240 mg daily, up to 320 mg daily may be required in some patients. As extended release tablet: 80 mg once daily, increased as needed every 3-7 days, average dose 160 mg once daily, max: 320 mg daily.   Hypertrophic cardiomyopathy Oral Adult - 10-40 mg, given 3-4 times daily. Hyperthyroidism Oral Adult - 10-40 mg, given 3-4 times daily. Anxiety Oral Adult - 40 mg once daily, may increase to bid-tid Essential tremor Oral Adult - 40 mg bid-tid. May increase at weekly intervals to 160 mg daily. Up to 320 mg daily may be necessary. Intravenous Emergency treatment of cardiac arrhythmias Adult - 1 mg injected over a period of 1 minute, repeated every 2 minutes, if needed. Max: 10 mg in conscious patients and 5 mg in patients under anaesthesia. Child  - 25-50 mcg/kg via slow injection, may be repeated 3-4 times daily. Intravenous Hyperthyroidism Adult - 1 mg, given over 1 minute, may repeat at 2-minute intervals until response is observed or a max of 10 mg is used in conscious patients or 5 mg in patients who are under anaesthesia. Food(before/after) Capsule May be taken with or without food. (Take consistently either always with or always without meals.) Tablet Should be taken on an empty stomach. (Take before meals.) List of Contraindications : Propranolol and Pregnancy Contraindicated in pregnancy Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.In 2nd & 3rd trimesters.Category D : There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).   Propranolol and Lactation : Caution when used during lactation Propranolol and Children Safety and effectiveness of Propranolol in pediatric patients have not been established. Bronchospasm and congestive heart failure have been reported coincident with the administration of Propranolol therapy in pediatric patients. Propranolol and Geriatic :In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of the decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.Propranolol and Other Contraindications : Sinus bradycardia, cardiogenic shock, pulmonary oedema, severe hyperactive airway disease, compensated cardiac failure, Raynaud's disease, hypoglycaemia, severe haemorrhage, metabolic acidosis, severe peripheral arterial disease, 2nd or 3rd degree heart block. Pregnancy (2nd and 3rd trimesters).Storage Intravenous Store at 20-25oC Oral Store at 20-25oC P - Contraindicated in pregnancy L - Contraindicated in lactation Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia. Pharmacokinetics : Flunarizine has H1-receptor blocking action and calcium-channel blocking effect. It has also been used as an adjunct epileptic therapy for patients refractory to standard treatment regimens. Absorption : Absorbed well from the GI tract (oral). Distribution : lipophilic. Protein-binding>90%. Metabolism Extensive. Excretion Via bile (as metabolites); 18 days (elimination half-life).   Flunarizine Adverse Reactions / Flunarizine Side Effects : Drowsiness. Rarely wt gain, headache, depression, gastric pain, dry mouth, insomnia, extrapyramidal reactions, galactorrhoea. Special Precautions : Driving or operating machinery, epilepsy, elderly, CVS disease, glaucoma. Other Drug Interactions : Plasma levels reduced by phenytoin, carbamazepine, valproic acid.Dosage Oral Prophylaxis of migraine, Prophylaxis of vertigo and vestibular disorders, Prophylaxis of peripheral and cerebrovascular disorders Adult - 5-10 mg daily at bedtime. Food(before/after) : May be taken with or without foodList of Contraindications Flunarizine and Pregnancy Contraindicated in pregnancy Flunarizine and Lactation Contraindicated in lactation Flunarizine and Other Contraindications Pregnancy, lactation, GI or urinary tract obstruction, acute porphyrias Fusilin-B Cream http://www.talinremedies.co.in/fusilin-b-cream.htm http://www.talinremedies.co.in/fusilin-b-cream.htm Tue, 13 Sep 2016 00:00:00 +0530 Uses : This medication is used to treat certain skin diseases (atopic dermatitis). It works by stopping the growth of certain bacteria and reducing redness, itching, crusting, and swelling of the skin sores. This medication is a combination of an antibiotic (fusidic acid) and a corticosteroid (Beclomethasone). This medication only treats certain bacterial infections. It will not work for other infections such as viral or fungal infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.   Details: Prescription - Yes Preparations - cream 0f 10 gm.   How to Use :  Clean and pat dry the affected skin areas before applying the medication. Gently massage a small amount into the affected areas three times daily, or as directed by your doctor. Do not bandage, wrap, or cover the area with an occlusive (plastic) dressing unless directed to do so by your doctor. If you are using this medication on the face, avoid applying it in or near the eye to prevent irritation or serious side effects (e.g., cataracts, glaucoma) that could occur with extended use. Use this medication for the full amount of time prescribed. Stopping the medication too early may allow bacteria to continue to grow. Do not apply to a larger area; use it more frequently or for a longer period of time than prescribed. Your condition will not improve faster, but the chance for side effects may be increased. Inform your doctor if your condition persists or worsens after 14 days of therapy.   Side Effects : Dryness, mild irritation, burning, or redness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Use of this medication for prolonged or repeated periods may result in skin discoloration/thinning, or a new infection (e.g., fungal infection). Contact your doctor if you notice signs of a new infection (e.g., new or worsening redness/irritation). A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.   Precautions : Before using this medication, tell your doctor or pharmacist if you are allergic to fusidic acid, Beclomethasone; or if you have any other allergies. Before using this medication, tell your doctor or pharmacist your medical history. Although very unlikely, it is possible this medication will be absorbed into your bloodstream. This may have undesirable consequences that may require additional corticosteroid treatment.  This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.   Drug Interactions : Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.   Overdose : This medication may be harmful if swallowed. If taken, contact your local poison control center or emergency room immediately. Notes : Do not share this medication with others. This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in those cases. Read the information provided with this medication to better understand your condition. Follow your doctor's or pharmacist's instructions on how to keep your skin clean and moisturized. Ask your pharmacist for advice on how to avoid skin irritants such as artificial fragrance, harsh cleansers, or wool clothing.Missed Dose : If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.STORAGE: Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.   Storage : Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Taliwet Eye Drops http://www.talinremedies.co.in/taliwet-eye-drops.htm http://www.talinremedies.co.in/taliwet-eye-drops.htm Tue, 13 Sep 2016 00:00:00 +0530 Taliwet Composition : Carboxymethylcellulose  Sodium I.P. .1% w/v Taliwet-PG Composition : Polyethylene IP   0.4% W/V Propylene Glycol  IP   0.3% W/V Dosage form Ophthalmic Solution (Eye drops) Description : Carboxymethyl cellulose is a lubricating agent, lubricates & moisturizes the dry irritated eyes. Indications : Taliwet is indicated for temporary relief from burning irritation and discomfort due to dryness of the eye or due to exposure to wind or sun. Dosage Instill 1 to 2 drops in the affected eye(s) as needed. Contraindications Hypersensitivity to any components of this medication. Warnings & precautions To avoid contamination do not touch tip of container to any surface. Replace cap after using. If you experience eye pain, changes in vision, continued redness or irritation of the eye and if the condition worsens or persists for more than 72 hours, discontinue use and consult a doctor. If solution changes color or becomes cloudy, do not use. Keep out of the reach of children. In case of accidental ingestion, seek professional assistance or consult your physician. Storage : Store in a cool dry place. Protect from light.Presentation : Taliwet Eye Drop is available in sterile FFS Pack of 10 ml.